WebApr 28, 2024 · Urothelium (transitional epithelium) is stratified and lines much of the urinary tract system. The superficial cells are rounded or dome-shaped with specialized … WebNormal urothelium was characterised by terminally differentiated superficial cells which expressed uroplakins in their luminal plasma membrane and cytokeratin 20 (CK20) in the cytoplasm. Basal and intermediate cells were CK20 negative and cytokeratin 17 (CK17) positive. In hyperplastic urothelium all cells synthesised CK17, but not CK20.
Uroplakin - an overview ScienceDirect Topics
WebThe GAG layer, specialized lipids, uroplakin proteins, and tight junction proteins create a high transepithelial resistance, allowing the urothelium to act as a fantastic barrier against irritative substances (Birder & Andersson, 2013 ). WebThe UROtsa cell line was isolated from a primary culture of normal human urothelium through immortalization with a construct containing the SV40 large T antigen. It proliferates in serum-containing growth medium as a cell monolayer with little evidence of … rv rental crystal beach
Renal Histology - SlideShare
WebThe cytosol contains a rich broth of macromolecules and smaller organic molecules, including glucose and other simple sugars, polysaccharides, amino acids, nucleic acids, and fatty acids. Ions of sodium, potassium, … WebUrothelium -protects the calyces, renal pelvis, ureters, and urinary bladder --protects underlying cells from hypertonic/toxic effects of urine Umbrella cells -large, bulbous superficial cells of the urothelium --apical membranes consist of hinged regions with dense plaques of uroplakin proteins that protect the cytoplasm Urinary bladder WebUrothelium specific proteins, uroplakins, were weakly expressed at early states of differentiation, but only in terminally differentiated cells did they organize into asymmetric … rv rental east texas