WebJul 3, 2024 · In asthma, epithelial cell-derived cytokines and chemokines (including IL-25, IL-33, thymic stromal lymphopoietin [TSLP], and granulocyte-macrophage colony-stimulating factor [GM-CSF]) signal … WebNov 30, 2024 · Asthma is a heterogeneous disease, originating from complex interactions between genetic and environmental factors, which consists of several different phenotypes sustained by cytokine-based biological mechanisms known as endotypes ( 16, 17 ).
Targeting cytokines to treat asthma and chronic obstructive
WebNov 1, 2001 · Studies in our laboratory have extended these latter studies by targeting CxCR4 and showing a reduction in T H 2 cytokines during asthma-type responses in mice (Lukacs et al., unpublished ... WebApr 16, 2024 · “Type 2-low” asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. … earl thomas flips off pete carroll
Molecular Targets for Biological Therapies of Severe Asthma
WebDec 23, 2024 · Using induced sputum samples, they identified airway bacterial and fungal microbiome profiles from adult participants with and without asthma and obesity (as … WebApr 16, 2024 · Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) … WebFeb 28, 2024 · Asthma that is uncontrolled despite prescribing of medium or high dose ICS-LABA treatment or that requires high dose ICS-LABA treatment to maintain good symptom control and reduce exacerbations. ... Particularly, biologics targeting type 2 cytokines and IgE showed significant efficacy in asthma outcomes such as exacerbations and lung … css sans serif fonts