Dianion alkylation
WebAug 13, 2006 · An efficient, scaleable synthesis approach towards the spirocyclic oxindole analogue 1’-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4’-piperidine]-5-carboxylic acid (1) is described. The key steps are dianion alkylation and cyclization of ethyl 2- oxindoline-5-carboxylate (4) and demethylation of the resulting spirocyclic oxindole ethyl 1’-methyl-2 … WebA convenient synthesis of triply carbon-13 labeled 2,2-dimethyl-13 C 2-propionitrile-1-13 C is described.The synthetic sequence begins with commercially available propionic acid-1-13 C and methyl iodide-13 C with the application of a sequential dianion alkylation.The 2,2-dimethyl-13 C 2-propionitrile-1-13 C was carried on to triply labeled DOWCO 429 …
Dianion alkylation
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WebThe dianion of β-keto-esters reacts with α-chloroethers to yield δ-alkoxy-β-keto-esters which are useful intermediates in annelation reactions. ... Alkylation of β-keto-ester … WebJul 25, 2016 · The selective generation of selenoamide monoanion and dianion was achieved by reacting N-benzyl selenobenzamide with BuLi. Alkylation of the dianion with 1 equiv of electrophile took place at the carbon atom adjacent to the nitrogen atom, and subsequent hydrolysis produced functionalized selenoamides in good to high yields. …
WebMay 1, 2002 · ChemInform Abstract: THE PHENYLACETONE DIANION- ALKYLATION WITH IODOMETHANE. Chemischer Informationsdienst 1978, 9 (19) DOI: … WebJan 1, 1989 · Benzylcarbamate 1 was conveniently prepared in 92% with tbutylamine and benzyl chloroformate In CH2C12. Upon addition of 2.2 equivalents of secuLl to 1 (THF,8), a deep redolored solution was produced, characteristic of dianion formation. Dianion 2 underwent alkylation with a variety of 5413 Ta ble 1.
WebJul 25, 2016 · The selective generation of selenoamide monoanion and dianion was achieved by reacting N-benzyl selenobenzamide with BuLi. Alkylation of the dianion … WebJul 25, 1994 · The dianion of (1 R ), (2 S )-cyclohexane-1,2-dicarboxylic acid mono- (−)-menthyl ester reacts with alkyl bromides and an iodide to give alkylation with selectivities ranging from 7:1 to 32:1, the configuration of one product has …
Weban atom or group of atoms having a positive ( cation) or negative ( anion) electric charge by virtue of having gained or lost an electron; substances forming ions are called … hilary gledhillWebSep 2, 2010 · 2,4-Diphenylquinazoline (1) is reduced by sodium in tetrahydrofuran to a dianion 2. Alkylation of this dianion with methyl iodide, tert-butyl bromide, 1,3-dihalopropanes, and 1,4-dibromobutane is ... small world viderWebDec 19, 2014 · Syntheses of 2,5- and 3,5-disubstituted 7-aminoindoles are illustrated. Additionally, dianion alkylation of the allylic nitrile is demonstrated to furnish, after cyclization, 5,6-disubstituted 7-aminoindoles to further exemplify this scalable and high-yielding method. hilary gish\u0027s son barnaby william whitehallWebdianion I and II. You should read the abstract and look at Scheme 1 (p. 3082) and Table 4 (p. 3086). ... Enamines normally react with methyl iodide to give two products: one arising from alkylation at nitrogen and the second arising from alkylation at carbon. For example, Heating the mixture of C-alkylation and N-alkylation products gives only ... small world villa woodWebApr 5, 2024 · The cis- and trans-isomers of a silacycloheptene were selectively synthesized by the alkylation of a silyl dianion, a novel approach to strained cycloalkenes. The trans-silacycloheptene (trans-SiCH) was significantly more strained than the cis isomer, as predicted by quantum chemical calculations and confirmed by crystallographic signatures … small world vocabularyWebFeb 7, 2008 · Particularly, nitromethane (10) can be regarded as a d 1,d 1 multiple coupling reagent corresponding to a carbonyl dianion synthon . Scheme 4. ... The introduction of a further carbon framework containing the second hydroxy group is realized by a regioselective alkylation of ketone 55 with chloroalkane 56. small world visionWebAug 12, 2024 · (chemistry) Any anion carrying two negative charges ... Definition from Wiktionary, the free dictionary hilary gish wikipedia