Diaphanous related formin 3
WebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. WebNov 1, 2024 · Abnormalities in nuclear shape are a well-known feature of cancer, but their contribution to malignant progression remains poorly understood. Here, we show that depletion of the cytoskeletal regulator, Diaphanous-related formin 3 (DIAPH3), or the nuclear membrane-associated proteins, lamin A/C, in prostate and breast cancer cells, …
Diaphanous related formin 3
Did you know?
WebHere we define a role for the Diaphanous-related formin-3 (DIAPH3) as a non-canonical regulator of metastasis that restrains conversion to amoeboid cell behaviour in multiple … WebJul 1, 2024 · Diaphanous related formin 3 (DIAPH3) promotes tumorigenesis in hepatocellular carcinoma and lung adenocarcinoma, suggesting that DIAPH3 may be a …
The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The actin nucleation-promoting activity of S. cerevisiae formins has been localized to the FH2 domain. See more Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. … See more Formins have been found in all eukaryotes studied. In humans, 15 different formin proteins are present that have been classified in 7 subgroups. By contrast, yeasts contain … See more • Formin-2 See more Formins are characterized by the presence of three formin homology (FH) domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains. In addition, other domains are usually present, such as See more • MBInfo - Formin mediated actin nucleation See more WebApr 6, 2024 · These signaling pathways are downregulated in the combination treatment. We found some biomarkers modulated such as cell division cycle protein 20 homolog (CDC20), serine/threonine kinase polo-like kinase 1 (PLK1), diaphanous related formin 3 (DIAPH3) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B; Figure 3D).
WebNov 25, 2008 · Diaphanous-related formin-1 ( DRF1) Gene names Name DIAPH1 Synonyms DIAP1 Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > … WebMar 29, 2024 · DIAPH3 diaphanous related formin 3 [ (human)] Gene ID: 81624, updated on 5-Feb-2024 Summary This gene encodes a member of the diaphanous subfamily of …
WebNov 8, 2016 · Aside from the Arp2/3 complex, which serves as the main nucleator of branched actin filaments at the cup rim, the underlying mechanisms of actin assembly still remain elusive. Here, we analyzed the role of Diaphanous-related formin G (ForG) from Dictyostelium by biochemical, genetic, and imaging techniques. Our data demonstrate …
WebIn this study, we identify diaphanous-related formin 3 (DIAPH3), an actin nucleator, as a scaffold protein to initiate liquid-liquid phase separation (LLPS) and form abundant … order iced coffee starbucksWebThe N terminus consists of a Rho GTPase-binding domain (GBD), which is joint to the formin homology 3 (FH3). DAD can mediate autoinhibition through interactions with the … order id card online ncWebStudies indicate that diaphanous related formin 1 (DIAPH1) is essentially involved in microtubules (MTs)-dependent early adhesion of colon cancer cells. A 51-year-old … order id epic gamesWebMISCELLANEOUS . - Approximately one-third of patients eventually lose outer hair cell function and have profound sensorineural deafness (after 10 to 20 years) - Average age at onset 18.6 years. MOLECULAR BASIS . - Caused by mutation in the diaphanous-related formin 3 gene (DIAPH3, 614567.0001) irefer victoriaWebDIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling Cell Rep. 2024 Jan 10;42 (1):111986. doi: 10.1016/j.celrep.2024.111986. Online ahead of print. Authors ireferukcm firstsource.comWebDiaphanous homolog 3 (Diap3) overexpression causes progressive hearing loss and inner hair cell defects in a transgenic mouse model of human deafness. Dia1 and Dia2 are … ireflet.cg65.localWebOct 5, 2016 · DIAPH1 encodes human DIA1, a formin protein that elongates unbranched actin. The c.3634+1G>T DIAPH1 mutation causes autosomal dominant nonsyndromic sensorineural hearing loss, DFNA1, characterized by progressive deafness starting in childhood. The mutation occurs near the C-terminus of the diaphanous autoregulatory … irefer wales